benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

Base Information

Chemical Name:benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate
CAS No.:637330-38-2
Molecular Formula:C₄₅H₆₆N₂O₁₄Si₃
Molecular Weight:943.281
Hs Code.:

Synonyms:benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

Suppliers and Price of benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

There total 7 articles about benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 637330-37-1
benzyl [(2-nitro-4-hydroxymethylphenyl)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

: 637330-38-2
benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1039/b306236h

Reference yield:

: 148579-93-5
(2S,3R,4S,5S,6S)-2-(4-formyl-2-nitrophenoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 637330-38-2
benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / NaBH₄; silica / CHCl₃; propan-2-ol / 0 - 20 °C

2: 65 percent / NaOMe / methanol / -15 - 20 °C

3: 85 percent / imidazole / dimethylformamide / 8 h / 20 °C

4: 84 percent / DMAP / pyridine; CH₂Cl₂ / 20 °C

5: 72 percent / Ti(OEt)4; 4 Angstroem molecular sieves / toluene / 48 h / Heating

6: 85 percent / AcOH; TBAF / dimethylformamide

7: 54 percent / pyridine / CH₂Cl₂ / 20 °C

With pyridine; 1H-imidazole; dmap; titanium(IV) tetraethanolate; sodium tetrahydroborate; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium methylate; silica gel; acetic acid; In pyridine; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1039/b306236h

Reference yield:

: 148579-94-6
(25,3R,45,55,65)-2-(4-(hydroxymethyl)-2-nitrophenoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 637330-38-2
benzyl [(2-nitro-4-(4-nitrophenoxycarbonyloxymethyl)phenoxy)-2,3,4-tri-(O-tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / NaOMe / methanol / -15 - 20 °C

2: 85 percent / imidazole / dimethylformamide / 8 h / 20 °C

3: 84 percent / DMAP / pyridine; CH₂Cl₂ / 20 °C

4: 72 percent / Ti(OEt)4; 4 Angstroem molecular sieves / toluene / 48 h / Heating

5: 85 percent / AcOH; TBAF / dimethylformamide

6: 54 percent / pyridine / CH₂Cl₂ / 20 °C

With pyridine; 1H-imidazole; dmap; titanium(IV) tetraethanolate; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium methylate; acetic acid; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b306236h