ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate

Base Information

• Chemical Name: ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate
• CAS No.: 1391424-42-2
• Molecular Formula: C₂₉H₃₈N₄O₅
• Molecular Weight: 522.645
• Mol file: 1391424-42-2.mol

Synonyms:ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate

Chemical Property of ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate

There total 5 articles about ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-(2-methoxyethyl)-N-(pyridin-2-ylmethyl)amine (62402-19-1) + ethyl 3,5-bis(bromomethyl)-4-hydroxybenzoate (108817-11-4) → ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate (1391424-42-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 48h;

DOI:10.1021/ic300687y

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate (1391424-42-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water / 72 h / 0 - 55 °C / Cooling

2: hydrogen bromide; acetic acid / 0.25 h / 20 °C

3: triethylamine / dichloromethane / 48 h / 0 - 20 °C

With hydrogen bromide; acetic acid; triethylamine; sodium hydroxide; In dichloromethane; water;

DOI:10.1021/ic300687y

Reference yield:

2-methoxy-N-((pyridin-2-yl)methylene)ethanamine (150975-29-4) → ethyl 4-hydroxy-3,5-bis(((2-methoxyethyl)-(pyridin-2-ylmethyl)amino)methyl)benzoate (1391424-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0 - 20 °C

2: triethylamine / dichloromethane / 48 h / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/ic300687y

upstream raw materials:

pyridine-2-carbaldehyde

Ethyl 4-hydroxybenzoate

N-(2-methoxyethyl)-N-(pyridin-2-ylmethyl)amine

ethyl 3,5-bis(bromomethyl)-4-hydroxybenzoate