(2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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Chemical Name:(2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS No.:1448187-92-5
Molecular Formula:C₂₂H₂₁N₅O₂S
Molecular Weight:419.507
Hs Code.:

Synonyms:(2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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Chemical Property of (2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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Technology Process of (2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

There total 12 articles about (2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: (2S,4R)-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride

: 3939-15-9
6-fluoropyridine-2-carbonitrile

: 1448187-92-5
(2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 1h; Microwave irradiation;

Reference yield: 34.0%

: 1448189-90-9
(2S,4R)-4-hydroxy-N-{ [4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide hydrochloride

: 3939-15-9
6-fluoropyridine-2-carbonitrile

: 1448187-92-5
(2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 1448187-92-5
(2S,4R)-1-(6-cyanopyridin-2-yl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Cooling with ice

2: potassium acetate; palladium diacetate / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; methanol; 1,4-dioxane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 100 °C / Microwave irradiation

With hydrogenchloride; potassium acetate; palladium diacetate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;