2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid

Base Information

• Chemical Name: 2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid
• CAS No.: 110038-90-9
• Molecular Formula: C₁₆H₁₅ClO₄
• Molecular Weight: 306.746
• Mol file: 110038-90-9.mol

Synonyms:2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid

Chemical Property of 2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid

There total 8 articles about 2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetonitrile (110038-89-6) → 2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid (110038-90-9)

Guidance literature:

With sodium hydroxide; In ethanol; Heating; overnight;

DOI:10.1002/jhet.5570230641

Reference yield:

vanillin acetate (881-68-5) → 2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid (110038-90-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 81 percent / fuming HNO₃ / -20 °C

2: 79 percent / 1.) FeSO₄, aq. HCl, 2.) 15 N ammonium hydroxide; / 90 °C

3: 1.) aq. HCl, NaNO₂, 2.) Cu₂Cl₂; / 1.) water, 0 deg C, 2.) temperature below 5 deg C, 3.) heating on steam bath, 1 h;

4: 89 percent / NaBH₄ / propan-2-ol / 1 h / 70 °C

5: 60 percent / K₂CO₃ / dimethylformamide / 36 h / Ambient temperature

6: 100 percent / SOCl₂ / CH₂Cl₂ / 1.5 h / Heating

7: 64 percent / dimethylsulfoxide / 3 h / Ambient temperature

8: 87 percent / aq. 25percent NaOH / ethanol / Heating; overnight

With copper(I) chloride; hydrogenchloride; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; nitric acid; potassium carbonate; iron(II) sulfate; sodium nitrite; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1002/jhet.5570230641

Reference yield:

2-nitrovanillin (2450-26-2) → 2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetic acid (110038-90-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 79 percent / 1.) FeSO₄, aq. HCl, 2.) 15 N ammonium hydroxide; / 90 °C

2: 1.) aq. HCl, NaNO₂, 2.) Cu₂Cl₂; / 1.) water, 0 deg C, 2.) temperature below 5 deg C, 3.) heating on steam bath, 1 h;

3: 89 percent / NaBH₄ / propan-2-ol / 1 h / 70 °C

4: 60 percent / K₂CO₃ / dimethylformamide / 36 h / Ambient temperature

5: 100 percent / SOCl₂ / CH₂Cl₂ / 1.5 h / Heating

6: 64 percent / dimethylsulfoxide / 3 h / Ambient temperature

7: 87 percent / aq. 25percent NaOH / ethanol / Heating; overnight

With copper(I) chloride; hydrogenchloride; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; potassium carbonate; iron(II) sulfate; sodium nitrite; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1002/jhet.5570230641

upstream raw materials:

2-Chloro-3-methoxy-4-(phenylmethoxy)benzeneacetonitrile

vanillin acetate

2-nitrovanillin

2-amino-4-hydroxy-3-methoxy-benzaldehyde

Downstream raw materials:

α-<<<2-<2-Chloro-3-methoxy-4-(phenylmethoxy)phenyl>ethyl>amino>ethyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

α-<<<2-<2-Chloro-4-hydroxy-3-methoxy>ethyl>amino>methyl>-4-hydroxybenzenemethanol hydrochloride

6-Chloro-2,3,4,5-tetrahydro-8-hydroxy-1-(4-hydroxyphenyl)-7-methoxy-1H-3-benzazepine hydrochloride

2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide

Refernces