2450-26-2

Basic information

• Product Name: 4-HYDROXY-3-METHOXY-2-NITROBENZALDEHYDE
• Synonyms: AKOS B028869;4-HYDROXY-3-METHOXY-2-NITROBENZALDEHYDE;LABOTEST-BB LT00159049;2-Nitrovanillin;4-Hydroxy-2-Nitro-M-anisaldehyde;Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro-;NSC 95689
• CAS NO: 2450-26-2
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.14
• EINECS: 1592732-453-0
• Mol File: 2450-26-2.mol
• Article Data: 39

Chemical Properties

• Melting Point: 137-138 °C
• Boiling Point: 387.8°Cat760mmHg
• Flash Point: 188.4°C
• Appearance: /
• Density: 1.456g/cm³
• Vapor Pressure: 1.43E-06mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.40±0.25(Predicted)
• CAS DataBase Reference: 4-HYDROXY-3-METHOXY-2-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-3-METHOXY-2-NITROBENZALDEHYDE(2450-26-2)
• EPA Substance Registry System: 4-HYDROXY-3-METHOXY-2-NITROBENZALDEHYDE(2450-26-2)

Safety Data

• Hazardous Substances Data: 2450-26-2(Hazardous Substances Data)

Usage

Uses

4-hydroxy-3-methoxy-2-nitrobenzaldehyde is used in preparation of o-nitrolignin monomers as readily degradable lignin-generation agents for plants and degradation of lignin under UV irradiation.

InChI:InChI=1/C8H7NO5/c1-14-8-6(11)3-2-5(4-10)7(8)9(12)13/h2-4,11H,1H3

Upstream product

• 64-17-5 ethanol 
• 881-68-5 vanillin acetate 
• 7697-37-2 nitric acid 
• 121-33-5 vanillin 
• 55149-84-3 2-nitroveratraldehyde 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1148134-74-0 4-formyl-2-methoxy-3-nitrophenyl benzenesulfonate 
• 2698-69-3 4-formyl-2-methoxy-3-nitrophenyl acetate 

Downstream Products

• 15807-80-4 3,3'-dimethoxy-2,2'-dinitro-4,4'-carbonyldioxy-di-benzaldehyde 
• 101936-59-8 4-((Z)-4-acetoxy-3-methoxy-2-nitro-benzylidene)-2-phenyl-4H-oxazol-5-one 
• 846546-76-7 4-(4-acetoxy-3-methoxy-2-nitro-phenyl)-5-cyano-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 50545-37-4 3,4-dihydroxy-2-nitrobenzaldehyde 
• 170489-28-8 6,7-dimethoxyindole-3-carboxaldehyde 
• 322765-43-5 (+/-)-5,8,9,10,11,14-hexahydro-6H-15,16-dimethoxy-7,14-diazacycloundeca[a]indene-7,13-dimethoxy-7,14-diazacycloundeca[a]indene-7,13-dicarboxylic acid 13-methyl ester 7-phenyl ester 
• 1103519-64-7 C₁₈H₁₇NO₆ 
• 298-81-7 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one 
• 1032568-63-0 copanlisib 
• 1032570-71-0 5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-ol 
• 859171-93-0 2'-nitro-O-methoxyethoxymethyl-nonivamide 
• 859171-92-9 [3-methoxy-4-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-methanol 

Relevant articles and documents

Vanillin derivatives as the selective small molecule inhibitors of FtsZ

A series of vanillin derivatives have been designed and synthesized and their biological activities were also evaluated as potential inhibitors of FtsZ. These compounds were assayed for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. Compounds with potent antibacterial activities were tested for their FtsZ inhibitory activity. Compound 4u showed the most potent antibacterial activity with MIC of 0.28 μg/mL against E. coli strains and exhibited the most potent FtsZ inhibitory activity with polymerization IC50 of 2.1 μM. Docking simulation was performed to position compound 4u into the FtsZ active site to determine the probable binding conformation.

Synthesis and physico-chemical properties of nitrocaffeic acids

The synthesis and spectroscopic properties of the three isomers of nitrocaffeic acid are described. The three pKa s of each isomer were measured by UV-visible spectroscopy. The comparison of the UV-visible spectra of nitrocaffeic acids and those obtained from the reaction of caffeic acid with reactive nitrogen species led to the conclusion that the nitration of caffeic acid with acidic nitrite does not significantly occur and confirmed trie absence of nitration when caffeic acid reacts with peroxynitrite. Attempts to obtain free radical species from nitrocaffeic acids by classical methods showed a different reactivity to that of nitroaromatics and catechols. Nitrocaffeic acids do not autoxidize under aqueous basic conditions and are insensitive to t-BuOK or O2-. (two reactants known for their capabilities to oxidize catechols and reduce nitroaromatics). Nitroaromatic anion radicals may be obtained using sodium borohydride as reductant and are particularly stable under an uncontrolled atmosphere. Copyright

Class of large ring heterocyclic compound restraining HCV and manufacturing and uses thereof

The invention relates to a class of compounds that inhibit HCV. The compounds are represented by Formula A. The invention also relates to preparation and pharmaceutical use of the compounds.

METHOD FOR PREPARING DIPHENYLMETHANE DERIVATIVES

The present invention relates to an improved process for preparing a diphenyl methane derivative which is useful as an inhibitor of a sodium-dependent glucose transporter (SGLT). Since the process of the present invention is performed by convergent synthe