2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester

Base Information

• Chemical Name: 2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester
• CAS No.: 1403384-95-1
• Molecular Formula: C₁₁H₁₂N₂O₅S
• Molecular Weight: 284.293
• Mol file: 1403384-95-1.mol

Synonyms:2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester

Chemical Property of 2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester

There total 1 articles about 2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-hydroxy-5-nitrobenzoate (17302-46-4) + N,N-Dimethylthiocarbamoyl chloride (16420-13-6) → 2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester (1403384-95-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/ol302260n

Reference yield: 100.0%

2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester (1403384-95-1) → 2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester (1403384-97-3)

Guidance literature:

at 150 ℃; for 0.333333h;

DOI:10.1021/ol302260n

Reference yield:

2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester (1403384-95-1) → C24H18N2O8S4 (1403384-89-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 0.33 h / 150 °C

2.1: acetic acid; zinc / 0.75 h / Reflux

3.1: pyridine / 3 h / Reflux

4.1: potassium hydroxide / ethanol / 0.67 h / Inert atmosphere; Reflux

4.2: Inert atmosphere; Cooling with ice

With pyridine; acetic acid; potassium hydroxide; zinc; In ethanol;

DOI:10.1021/ol302260n

upstream raw materials:

methyl 2-hydroxy-5-nitrobenzoate

N,N-Dimethylthiocarbamoyl chloride

Downstream raw materials:

C₃₂H₃₂N₄O₁₀S₄

C₂₄H₁₈N₂O₈S₄

2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester

5-amino-2-((dimethylcarbamoyl)sulfanyl) benzoic acid methyl ester