2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester

Base Information

• Chemical Name: 2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester
• CAS No.: 1403384-97-3
• Molecular Formula: C₁₁H₁₂N₂O₅S
• Molecular Weight: 284.293
• Mol file: 1403384-97-3.mol

Synonyms:2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester

Chemical Property of 2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester

There total 2 articles about 2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester (1403384-95-1) → 2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester (1403384-97-3)

Guidance literature:

at 150 ℃; for 0.333333h;

DOI:10.1021/ol302260n

Reference yield:

methyl 2-hydroxy-5-nitrobenzoate (17302-46-4) → 2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester (1403384-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 48 h / 20 °C

2: 0.33 h / 150 °C

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide;

DOI:10.1021/ol302260n

Reference yield: 73.0%

2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester (1403384-97-3) → 2-mercapto-5-nitrobenzoic acid (99334-37-9)

Guidance literature:

With sodium hydroxide; In methanol; water; for 16h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.9b01679

upstream raw materials:

methyl 2-hydroxy-5-nitrobenzoate

2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester

Downstream raw materials:

C₃₂H₃₂N₄O₁₀S₄

5-amino-2-((dimethylcarbamoyl)sulfanyl) benzoic acid methyl ester

2-mercapto-5-nitrobenzoic acid