tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane

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Chemical Name:tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane
CAS No.:84927-73-1
Molecular Formula:C₃₂H₅₄O₂Si
Molecular Weight:498.865
Hs Code.:

tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane

Synonyms:tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane

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Chemical Property of tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane

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Technology Process of tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane

There total 10 articles about tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 84927-69-5
(1R,3aR,7aR)-7a-Methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-4-one

: 100858-27-3
(S)-(Z)-{2-[5-(tert-butyldimethylsiloxy)-2-methylenecyclohexylidene]ethyl}diphenylphosphine oxide

: 84927-73-1
tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; for 1.25h; -78 deg C to room temp.;
DOI:10.1021/jo00157a004

Reference yield:

: 67-97-0
vitamin D₃

: 84927-73-1
tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / potassium permanganate / H₂O; ethanol / 1.) -10 deg C, 1 h, 2.) to 40 deg C, 10 min

2: 86 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

3: 1.) lead tetraacetate, 2.) Red-Al / 1.) benzene, pyridine, 25 deg C, 10 min, 2.) water, 1,5h

4: 91 percent / N-chlorosuccinimide, dimethyl sulfide / 1.) CH₂Cl₂, -20 deg C, 30 min, 2.) 0 deg C, 30 min

5: 1.) n-butyllithium, 2.) 5percent H₂O₂ / 1.) hexane, THF,-50 deg C, 15 min, 2.) chloroform, 1 min

6: 73 percent / n-butyllithium / tetrahydrofuran / 1.25 h / -78 deg C to room temp.

With 1H-imidazole; lead(IV) acetate; potassium permanganate; N-chloro-succinimide; n-butyllithium; dimethylsulfide; dihydrogen peroxide; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00157a004

Reference yield:

: 64190-52-9
(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

: 84927-73-1
tert-Butyl-dimethyl-{(S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(S)-1-methyl-2-(2-methyl-allyloxy)-ethyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyloxy}-silane

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / 1.) THF, hexane, 0 deg C, 2.) DMF, 75 to 78 deg C, 1.5h

2: 91 percent / pyridinium trifluoroacetate, pyridinium dichromate / CH₂Cl₂ / 4 h / Ambient temperature

3: 73 percent / n-butyllithium / tetrahydrofuran / 1.25 h / -78 deg C to room temp.

With dipyridinium dichromate; n-butyllithium; pyridinium trifluroacetate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00157a004