100858-27-3

Basic information

• Product Name: tert-Butyl-{3-[2-(diphenyl-phosphinoyl)-ethylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane
• Synonyms: tert-Butyl-{3-[2-(diphenyl-phosphinoyl)-ethylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane;(S,Z)-(2-(5-((tert-butyldiMethylsilyl)oxy)-2-Methylenecyclohexylidene)ethyl)diphenylphosphine oxide;[S-(Z)]-[2-[5-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethyl]diphenylphosphine Oxide;tert-Buty-(3-(2-(diphenyl-phosphinoy)-ethylidene)-4-methylenecyclohexyloxy)-dimethyl-silane;Phosphine oxide,[(2Z)-2-[(5S)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethyl]diphenyl-;tert-Butyl-[(1S,3Z)-3-(2-diphenylphosphorylethylidene)-4-methylene-cyclohexoxy]-dimethyl-silane;tert-Butyl-[3-(2-diphenylphosphorylethylidene)-4-methylidenecyclohexyl]oxy-dimethylsilane;(S)-tert-Butyl-{3-[2-(diphenyl-phosphinoyl)-ethylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane
• CAS NO: 100858-27-3
• Molecular Formula: C₂₇H₃₇O₂PSi
• Molecular Weight: 452.64
• Mol File: 100858-27-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 507.183 °C at 760 mmHg
• Flash Point: 260.535 °C
• Appearance: /
• Density: 1.048 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.539
• Solubility: DCM, Methanol
• CAS DataBase Reference: tert-Butyl-{3-[2-(diphenyl-phosphinoyl)-ethylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl-{3-[2-(diphenyl-phosphinoyl)-ethylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane(100858-27-3)
• EPA Substance Registry System: tert-Butyl-{3-[2-(diphenyl-phosphinoyl)-ethylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane(100858-27-3)

Safety Data

• Hazardous Substances Data: 100858-27-3(Hazardous Substances Data)

Usage

Uses

[S-(Z)]-[2-[5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethyl]diphenylphosphine Oxide is an intermediate in the synthesis of Vitamin D3 derivatives.

InChI:InChI=1/C27H37O2PSi/c1-22-17-18-24(29-31(5,6)27(2,3)4)21-23(22)19-20-30(28,25-13-9-7-10-14-25)26-15-11-8-12-16-26/h7-16,19,24H,1,17-18,20-21H2,2-6H3/b23-19-/t24-/m0/s1

Upstream product

• 50-14-6 Calciferol 
• 84985-78-4 (4R,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-4-((R,Z)-1-hydroxy-2-((S)-5-hydroxy-2-methylenecyclohexylidene)ethyl)-7a-methyloctahydro-1H-inden-4-ol 
• 67337-15-9 <(1Z),(5S)>-2-<5-hydroxy-2-methylcyclohexylidene>-ethanol 
• 1014717-75-9 (S,Z)-tert-butyl(2-(5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethoxy)dimethylsilane 
• 829-85-6 diphenylphosphane 
• 84927-67-3 3β-O-(tert-butyldimethylsilyl)-7,8-dihydroxy-7,8-dihydrovitamin D3 
• 84927-66-2 7,8-dihydroxy-7,8-dihydrovitamin D₃ 
• 96685-53-9 (2Z)-2-<(5S)-5-(tert-butyldimethylsilyloxy)-2-methylene-cyclohexylidene>-ethanol 
• 67-97-0 vitamin D₃ 
• 138313-18-5 <(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane 
• 4559-70-0 Diphenylphosphine oxide 
• 1236132-10-7 (S)-(Z)-[2-(5-hydroxy-2-methylene-cyclohexylidene)ethyl]di-phenylphosphineoxide 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 393184-85-5 Toluene-4-sulfonic acid (S)-2-((S)-1-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethyl)-5-methyl-5-triethylsilanyloxy-hexyl ester 
• 725227-35-0 2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol 
• 725227-40-7 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 84927-61-7 23-oxa-25-hydroxyvitamin D₃ 
• 84927-72-0 23-oxa-25,26-dehydrovitamin D₃ 
• 1186587-54-1 C₃₇H₆₆O₂Si₂ 
• 1236132-08-3 3β-O-(tert-butyldimethylsilyl)-11α-(7-ethoxycarbonylhept-1-yl)-vitamin D3 
• 1236132-10-7 (S)-(Z)-[2-(5-hydroxy-2-methylene-cyclohexylidene)ethyl]di-phenylphosphineoxide 
• 651734-12-2 20S-Hydroxyvitamin D₃ 
• 1372617-13-4 20,25-dihydroxyvitamin D₃ 
• 140710-90-3 (R)-6-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2-methyl-heptan-2-ol 

Relevant articles and documents

Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D3, 20S,25(OH)2D3, 20S,23S(OH)2D3 and 20S,23R(OH)2D3

New and more efficient routes of chemical synthesis of vitamin D3 (D3) hydroxy (OH) metabolites, including 20S(OH)D3, 20S,23S(OH)2D3 and 20S,25(OH)2D3, that are endogenously prod

Synthesis of Retiferol RAD1 and RAD2, the Lead Representatives of a New Class of des-CD Analogs of Cholecalciferol

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