1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Base Information

Chemical Name:1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)
CAS No.:209349-01-9
Molecular Formula:C₂₉H₃₃ClN₂O₂S₂
Molecular Weight:541.178
Hs Code.:

Synonyms:1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

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Chemical Property of 1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Chemical Property:

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Technology Process of 1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

There total 9 articles about 1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,3-dihydrobenzo-thiophene-3,4'-piperidine hydrochloride

: 3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)-(methylamino))butanal

: 98-09-9
benzenesulfonyl chloride

: 209349-01-9
1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Guidance literature:: With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; silica gel; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 209160-93-0
(S)-(3-(3-chlorophenyl))-4-(N-methyl-N-phenylsulfonylamino)butanal

: spiro[2,3-dihydrobenzothiophene]-3,4'-piperidine hydrochloride

: 209349-01-9
1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Guidance literature:: With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1016/S0960-894X(00)00639-9

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 209349-01-9
1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Guidance literature:: Multi-step reaction with 4 steps

1: DIPEA / CH₂Cl₂ / 20 °C

2: OsO₄; NMO; H₂O / acetone; 2-methyl-propan-2-ol / 20 °C

3: aq. NaIO₄ / tetrahydrofuran / 20 °C

4: DIPEA; NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; water; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetone; tert-butyl alcohol;
DOI:10.1016/S0960-894X(00)00639-9