N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile

Base Information

• Chemical Name: N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile
• CAS No.: 109912-33-6
• Molecular Formula: C₂₂H₃₀N₄O
• Molecular Weight: 366.506
• Mol file: 109912-33-6.mol

Synonyms:N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile

Chemical Property of N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile

There total 6 articles about N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Desmethylpyrilamine (104499-47-0) → N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile (109912-33-6)

Guidance literature:

With sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetonitrile; at 60 ℃; for 2h;

DOI:10.3390/molecules181114186

Reference yield:

6-bromo-1-hexanenitrile (6621-59-6) + N-Desmethylpyrilamine (104499-47-0) → N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile (109912-33-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1016/0223-5234(87)90002-X

Reference yield:

2-[(pyridin-2-yl)amino]ethylamine (74764-17-3) → N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-6-aminohexanonitrile (109912-33-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min

2: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C

3: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

4: potassium carbonate / dimethylformamide / 2 h / 100 °C

With lithium aluminium tetrahydride; acetic anhydride; sodium hydride; potassium carbonate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(87)90002-X

upstream raw materials:

6-bromo-1-hexanenitrile

N-Desmethylpyrilamine

2-bromo-pyridine

2-[(pyridin-2-yl)amino]ethylamine

Downstream raw materials:

N-cyano-N'-[6-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]hexyl]-N''-[3-[3-(piperidinomethyl)phenoxy]propyl]guanidine

N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-N''-[6-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]hexyl]guanidine

N¹-{2-[(4-Methoxy-benzyl)-pyridin-2-yl-amino]-ethyl}-N¹-methyl-hexane-1,6-diamine