(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid

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Chemical Name:(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid
CAS No.:194484-86-1
Molecular Formula:C₃₂H₄₈N₄O₁₀
Molecular Weight:648.754
Hs Code.:

(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid

Synonyms:(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid

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Chemical Property of (S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid

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Technology Process of (S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid

There total 4 articles about (S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 194484-86-1
(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: tetrahydrofuran; dimethylformamide / 6 h / -10 - 20 °C

3: 94 percent / H₂ / 10percent Pd/C / H₂O; methanol / 760 Torr / Ambient temperature

4: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm9701132

Reference yield:

: C₂₄H₃₆N₂O₈

: 194484-86-1
(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; dimethylformamide / 6 h / -10 - 20 °C

2: 94 percent / H₂ / 10percent Pd/C / H₂O; methanol / 760 Torr / Ambient temperature

3: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm9701132

Reference yield:

: 90826-23-6
N-(N²-benzyloxycarbonyl-N⁶-tert-butoxycarbonyl-L-lysyl)-L-proline benzyl ester

: 194484-86-1
(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-6-tert-butoxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / H₂ / 10percent Pd/C / H₂O; methanol / 760 Torr / Ambient temperature

2: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm9701132