tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

Base Information

Chemical Name:tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate
CAS No.:1206965-53-8
Molecular Formula:C₂₂H₂₄N₂O₃
Molecular Weight:364.444
Hs Code.:

Synonyms:tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

Suppliers and Price of tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

There total 6 articles about tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 863724-37-2
tert-butyl (8-bromo-2-oxo-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

: 98-80-6
phenylboronic acid

: 1206965-53-8
tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 20 ℃; for 2.5h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2012.12.024

Reference yield:

: 94567-78-9
3,4-dihydro-2H-quinoline-1-carboxylic acid methyl ester

: 1206965-53-8
tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice; Inert atmosphere

2: nitronium tetrafluoborate / acetonitrile / 1 h / Cooling with ice; Inert atmosphere

3: acetic acid; iron / 2 h / 80 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C / Cooling with ice; Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 20 °C / Reflux; Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nitronium tetrafluoborate; iron; potassium carbonate; acetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; 5: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.12.024

Reference yield:

: 139525-70-5
methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate

: 1206965-53-8
tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: nitronium tetrafluoborate / acetonitrile / 1 h / Cooling with ice; Inert atmosphere

2: acetic acid; iron / 2 h / 80 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C / Cooling with ice; Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 20 °C / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; nitronium tetrafluoborate; iron; potassium carbonate; acetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; 4: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.12.024