methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate

Base Information

Chemical Name:methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate
CAS No.:139525-70-5
Molecular Formula:C11H12BrNO2
Molecular Weight:270.12200
Hs Code.:
DSSTox Substance ID:DTXSID90415462
Mol file:139525-70-5.mol

Synonyms:139525-70-5;methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate;1(2H)-Quinolinecarboxylic acid, 6-bromo-3,4-dihydro-, methyl ester;SCHEMBL5413736;DTXSID90415462;STK736528;AKOS003390156;CS-0324394;methyl6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate;methyl 6-bromo-3,4-dihydro-1(2H)-quinolinecarboxylate;methyl 6-bromo-1,2,3,4-tetrahydroquinoline-1-carboxylate

Suppliers and Price of methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 97%
1g
$ 401.00

Crysdot
Methyl6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 97%
5g
$ 1116.00

Crysdot
Methyl6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 97%
10g
$ 1563.00

Chemenu
Methyl6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 97%
10g
$ 1473.00

Chemenu
Methyl6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 97%
5g
$ 1052.00

Chemenu
Methyl6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 97%
1g
$ 379.00

Total 2 raw suppliers

Chemical Property of methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate

Chemical Property:

PSA：29.54000
LogP:3.03310
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:269.00514
Heavy Atom Count:15
Complexity:247

Purity/Quality:

99% ^*data from raw suppliers

Methyl6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)N1CCCC2=C1C=CC(=C2)Br

Technology Process of methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate

There total 2 articles about methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 94567-78-9
3,4-dihydro-2H-quinoline-1-carboxylic acid methyl ester

: 139525-70-5
methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 3h;

Reference yield:

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 139525-70-5
methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 50 °C / Cooling with ice; Inert atmosphere

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice; Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.12.024

Reference yield:

: 139525-70-5
methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate

: 775-12-2
diphenylsilane

: C₂₃H₂₂BrNO₂Si

: C₂₃H₂₂BrNO₂Si

Guidance literature:: diphenylsilane; With copper diacetate; Tri(p-tolyl)phosphine; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane; In neat (no solvent); at 30 ℃; for 0.5h; Sealed tube; Inert atmosphere;

methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate; In neat (no solvent); at 40 ℃; for 36h; Overall yield = 50 percent; Overall yield = 44.8 mg; enantioselective reaction; Sealed tube; Inert atmosphere;
DOI:10.1055/s-0040-1707134