N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Base Information

Chemical Name:N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide
CAS No.:1410039-27-8
Molecular Formula:C₂₁H₂₀FN₇O₂
Molecular Weight:421.434
Hs Code.:

Synonyms:N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

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Chemical Property of N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

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Technology Process of N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

There total 7 articles about N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107504-08-5
5-fluoropicolinic acid

: C₁₅H₁₉N₅O₂

: 1410039-27-8
N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: 5-fluoropicolinic acid; C₁₅H₁₉N₅O₂; With di(2H-imidazol-2-yl)methanone; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 2h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; acetonitrile; at 70 ℃; for 1h;
DOI:10.1016/j.bmc.2015.01.044

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1410039-27-8
N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / chloroform / 1 h / 0 °C / Reflux

2.1: triethylamine / chloroform / 16 h / 0 - 20 °C

3.1: triethylamine / chloroform / 1 h / 20 °C / Cooling with ice

4.1: N,N-dimethyl-formamide / 3.5 h / 80 °C

5.1: hydroxylamine / ethanol; water / 4 h / 80 °C

6.1: di(2H-imidazol-2-yl)methanone / acetonitrile; N,N-dimethyl-formamide / 2 h / 20 °C

6.2: 1 h / 70 °C

With thionyl chloride; hydroxylamine; triethylamine; di(2H-imidazol-2-yl)methanone; In ethanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2015.01.044

Reference yield:

: 1104546-96-4
5-methyl-2-(2Η-1,2,3-triazol-2-yl)benzoyl chloride

: 1410039-27-8
N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / chloroform / 16 h / 0 - 20 °C

2.1: triethylamine / chloroform / 1 h / 20 °C / Cooling with ice

3.1: N,N-dimethyl-formamide / 3.5 h / 80 °C

4.1: hydroxylamine / ethanol; water / 4 h / 80 °C

5.1: di(2H-imidazol-2-yl)methanone / acetonitrile; N,N-dimethyl-formamide / 2 h / 20 °C

5.2: 1 h / 70 °C

With hydroxylamine; triethylamine; di(2H-imidazol-2-yl)methanone; In ethanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2015.01.044