(+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol

Base Information

Chemical Name:(+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol
CAS No.:281658-46-6
Molecular Formula:C₂₁H₃₄O₄Si
Molecular Weight:378.584
Hs Code.:

Synonyms:(+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol

Suppliers and Price of (+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol

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Technology Process of (+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol

There total 2 articles about (+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 87184-81-4
4-(tert-butyldimethylsilanyloxy)butanal

: C₁₁H₁₁LiO₂

: 281658-46-6
(+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol

Guidance literature:: In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4020(99)01103-5

Reference yield:

: 87184-99-4
4-tert-butyldimethylsilyloxybutan-1-ol

: 281658-46-6
(+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: DMSO; oxallyl chloride / CH₂Cl₂ / 90 h / -78 °C

1.2: Et₃N / CH₂Cl₂ / -78 - 20 °C

2.1: 72 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

With oxallyl chloride; dimethyl sulfoxide; In tetrahydrofuran; hexane; dichloromethane; 1.1: Oxidation / 1.2: Oxidation / 2.1: Alkylation;
DOI:10.1016/S0040-4020(99)01103-5

Reference yield: 99.0%

: 281658-46-6
(+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol

: 281658-47-7
7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-one

Guidance literature:: (+/-)-7-(tert-butyldimethylsiloxy)-1-[(p-methoxybenzyl)oxy]-2-heptyn-4-ol; With oxallyl chloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 90h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(99)01103-5