4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&

Base Information

• Chemical Name: 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&
• CAS No.: 87184-99-4
• Molecular Formula: C10H24O2Si
• Molecular Weight: 204.385
• Mol file: 87184-99-4.mol

Synonyms:4-(DIMETHYL-TERT-BUTYLSILYLOXY)BUTAN-1-OL;1-t-butyldimethylsilyloxy-4-hydroxybutane;1-(tert-Butyldimethylsilyloxy)-4-butanol;4-hydroxy-1-t-butyldimethylsiloxybutane;4-TBSO(CH2)4OH;1-(dimethyl-tert-butylsilyloxy)-butan-4-ol;1,4-Butanediol mono-tertbutyldimethylsilyl ether;4-(tert-Butyldimethylsilyl)oxy-1-butanol;4-OTBS butan-1-ol;

Chemical Property of 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&

Chemical Property:

• Vapor Pressure: 0.0128mmHg at 25°C
• Refractive Index: n20/D 1.4390(lit.)
• Boiling Point: 230.1°Cat760mmHg
• PKA: 15.07±0.10(Predicted)
• Flash Point: 92.9°C
• PSA: 29.46000
• Density: 0.876g/cm³
• LogP: 2.78070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly Soluble in water.(2.0 g/L) (25°C). Soluble in Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Dimethyl-tert-Butylsilyloxy)butan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-(Dimethyl-tert-Butylsilyloxy)butan-1-ol (cas# 87184-99-4) is a compound useful in organic synthesis.

Technology Process of 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&

There total 6 articles about 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

allyl 4-(tert-butyldimethylsilyloxy)butylcarbonate (1333925-48-6) + 2-propanethiol (75-33-2) → allylisopropyl sulfide (50996-72-0) + carbon dioxide (124-38-9,18923-20-1) + 4-tert-butyldimethylsilyloxybutan-1-ol (87184-99-4)

Guidance literature:

With [Bu₄N][Fe(CO)3(NO)]; tris(2,4,6-trimethylphenyl)phosphine; In ethanol; at 40 ℃; Inert atmosphere;

DOI:10.1021/ol202270g

Reference yield: 83.0%

[4-(benzyloxy)butoxy](tert-butyl)dimethylsilane (105966-46-9) → Butane-1,4-diol (110-63-4) + 4-tert-butyldimethylsilyloxybutan-1-ol (87184-99-4)

Guidance literature:

With Ti-HMS; hydrogen; 5% Pd on active carbon; In methanol; for 3h; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(98)02145-5

Reference yield: 83.0%

1-tert-butyldimethylsilyloxy-4-triethylsilyloxybutane (117785-64-5) → Butane-1,4-diol (110-63-4) + 4-tert-butyldimethylsilyloxybutan-1-ol (87184-99-4)

Guidance literature:

With MCM-41; In methanol; for 4h; Ambient temperature;

upstream raw materials:

4-(tert-butyldimethylsilyloxy)butyric acid methyl ester

1-tert-butyldimethylsilyloxy-4-triethylsilyloxybutane

[4-(benzyloxy)butoxy](tert-butyl)dimethylsilane

4-(tert-butyldimethylsilanyloxy)butanal

Downstream raw materials:

butane-1,4-diol diacetate

tert-butyldimethyl((4-(3-phenylpropoxy)hex-5-en-1-yl)oxy)silane

1-({4-[(tert-butyl)dimethylsilyloxy]butoxy}methyl)-4-ethenylbenzene

Refernces

• 1、 Itoh, Akichika,Kodama, Tomohiro,Masaki, Yukio. "Deprotection of a silyl group with mesoporous silica". . p. 861 - 864. Retrieved 2008/02/11.
• 2、 De Figueiredo, Renata Marcia,Froehlich, Roland,Christmann, Mathias. "N,N′-carbonyldiimidazole-mediated cyclization of amino alcohols to substituted azetidines and other N-heterocycles". . p. 4147 - 4154. Retrieved 2007/10/03.