phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide

Base Information

• Chemical Name: phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide
• CAS No.: 1257216-18-4
• Molecular Formula: C₁₃H₁₈N₂O₂*HI
• Molecular Weight: 362.211
• Mol file: 1257216-18-4.mol

Synonyms:phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide

Chemical Property of phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide

Chemical Property:

Purity/Quality:

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Technology Process of phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide

There total 1 articles about phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bis(phenyl) carbonate (102-09-0) + (1R,2R)-1,2-diaminocyclohexane tartrate (32044-22-7,39961-95-0) → phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide (1257216-18-4)

Guidance literature:

bis(phenyl) carbonate; (1R,2R)-1,2-diaminocyclohexane tartrate; In isopropyl alcohol; Reflux;

With methanesulfonic acid; at 110 ℃; for 1h; Inert atmosphere;

With potassium iodide; In water; at 0 ℃;

DOI:10.1021/jo101723v

Reference yield: 96.0%

phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide (1257216-18-4) + 4-methyl-benzoyl chloride (874-60-2) → C21H24N2O3 (1257216-15-1)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

DOI:10.1021/jo101723v

Reference yield: 89.0%

phenyl (1R,2R)-2-aminocyclohexylcarbamate hydroiodide (1257216-18-4) + p-toluenesulfonyl chloride (98-59-9) → C20H24N2O4S (1257216-14-0)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 4h;

DOI:10.1021/jo101723v

upstream raw materials:

bis(phenyl) carbonate

(1R,2R)-1,2-diaminocyclohexane tartrate

Downstream raw materials:

C₂₁H₂₄N₂O₃

C₂₀H₂₄N₂O₄S

C₂₅H₃₁N₃O₄