(2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid

Base Information

• Chemical Name: (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid
• CAS No.: 1213432-11-1
• Molecular Formula: C₁₅H₂₀INO₄
• Molecular Weight: 405.233
• Mol file: 1213432-11-1.mol

Synonyms:(2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid

Chemical Property of (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid

There total 1 articles about (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-2-((tert-butoxycarbonyl)amino)-3-(3-iodophenyl)propanoic acid (273221-75-3) + methyl iodide (74-88-4) → (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid (1213432-11-1)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1002/ejoc.201601215

Reference yield: 63.0%

(2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid (1213432-11-1) + trimethylsilylacetylene (1066-54-2) → C20H29NO4Si

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1002/ejoc.201601215

Reference yield: 52.0%

(2S)-2-[(tert-butoxycarbonyl)amino]-3-(3-iodophenyl)propanoic acid (1213432-11-1) → (S)-tert-butyl (1-hydroxy-3-(3-iodophenyl)propan-2-yl)carbamate

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 1.25h;

upstream raw materials:

(S)-2-((tert-butoxycarbonyl)amino)-3-(3-iodophenyl)propanoic acid

methyl iodide

Downstream raw materials:

tert-butyl ((1S)-2-hydroxy-1-{3-[(trimethylsilyl)ethynyl]benzyl}ethyl)carbamate

(2S)-2-amino-3-{3-[(trimethylsilyl)ethynyl]phenyl}propan-1-ol

5-bromo-2-((1S)-2-hydroxy-1-{3-[(trimethylsilyl)ethynyl]benzyl}ethyl)isoindolin-1-one

2-((2S)-2-(5-bromo-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-3-{3-[(trimethylsilyl)ethynyl]phenyl}propyl)-1H-isoindole-1,3(2H)-dione