5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide

Base Information

• Chemical Name: 5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide
• CAS No.: 636992-66-0
• Molecular Formula: C₂₉H₂₆N₄O₅
• Molecular Weight: 510.549

Synonyms:5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide

Chemical Property of 5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide

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Technology Process of 5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide

There total 5 articles about 5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloroacetyl)benzenecarbonitrile (40805-50-3) → 5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide (636992-66-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / K₂CO₃

2: 40.9 percent / tri-o-tolylphosphine; Et₃N / Pd(OAc)2 / tetrahydrofuran

3: tetrahydrofuran

With potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; 2: Heck reaction;

DOI:10.1039/b307468d

Reference yield:

(E)-N,N-diethyl-2-butenamide (1950-58-9) → 5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide (636992-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 40.9 percent / tri-o-tolylphosphine; Et₃N / Pd(OAc)2 / tetrahydrofuran

2: tetrahydrofuran

With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; 1: Heck reaction;

DOI:10.1039/b307468d

Reference yield:

5-bromo-2-hydroxybenzonitrile (40530-18-5) → 5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide (636992-66-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / K₂CO₃

2: 40.9 percent / tri-o-tolylphosphine; Et₃N / Pd(OAc)2 / tetrahydrofuran

3: tetrahydrofuran

With potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; 2: Heck reaction;

DOI:10.1039/b307468d

upstream raw materials:

5-methyl-3-isoxazolyl chloride

(E)-3-[3-amino-2-(4-cyanobenzoyl)benzo[b]furan-5-yl]but-2-enoic acid diethylamide

(E)-N,N-diethyl-2-butenamide

5-bromo-2-hydroxybenzonitrile

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