1950-58-9

Basic information

• Product Name: 2-ButenaMide, N,N-diethyl-, (E)-
• Synonyms: 2-ButenaMide, N,N-diethyl-, (E)-
• CAS NO: 1950-58-9
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.2108
• Mol File: 1950-58-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 242.6°C at 760 mmHg
• Flash Point: 101.9°C
• Appearance: /
• Density: 0.89g/cm³
• Vapor Pressure: 0.0336mmHg at 25°C
• Refractive Index: 1.453
• CAS DataBase Reference: 2-ButenaMide, N,N-diethyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ButenaMide, N,N-diethyl-, (E)-(1950-58-9)
• EPA Substance Registry System: 2-ButenaMide, N,N-diethyl-, (E)-(1950-58-9)

Safety Data

• Hazardous Substances Data: 1950-58-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H15NO/c1-4-7-8(10)9(5-2)6-3/h4,7H,5-6H2,1-3H3/b7-4+

Upstream product

• 4894-61-5 trans-but-2-enyl chloride 
• 109-89-7 diethylamine 
• 10487-71-5 crotonyl chloride 
• 590-14-7 1-bromo-1-propene 
• 623-43-8 crotonic acid methyl ester 
• 4419-47-0 tetrakis(diethylamino)titanium 
• 625-35-4 trans-chrotonyl chloride 
• 107-93-7 (E)-but-2-enoic acid 

Downstream Products

• 636992-58-0 (E)-[2-cyano-4-(2-diethylcarbamoyl-1-methylvinyl)phenoxy]acetic acid ethyl ester 
• 636992-57-9 (E)-3-[3-amino-2-(4-cyanobenzoyl)benzo[b]furan-5-yl]but-2-enoic acid diethylamide 
• 636992-66-0 5-Methyl-isoxazole-3-carboxylic acid [2-(4-cyano-benzoyl)-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-benzofuran-3-yl]-amide 
• 803684-91-5 (E)-N-[2-(4-cyanobenzoyl)-5-(2-diethylcarbamoyl-1-methylvinyl)benzofuran-3-yl]-5-methylisoxazole-4-carboxamide 
• 467426-62-6 trans-N,N-diethyl-2-methylcyclopropanecarboxamide 

Relevant articles and documents

Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/keap1 pathway

Parkinson's disease (PD) is a slowly progressive and complex neurodegenerative disorder. Up to date, there are no approved drugs that could slow or reverse the neurodegenerative process of PD. Here, we reported the synthesis of series of piperine analogues and the evaluation of their neuroprotective effects against hydrogen peroxide (H2O2) induced damage in the neuron-like PC12 cells. Among these analogues, 3b exhibited the most potent protection effect and its underlying mechanism was further investigated. Further results indicated that the ROS scavenging and cytoprotection effect of 3b might be related to the Nrf2 activation and upregulation of related phase II antioxidant enzymes, such as HO-1 and NQO1. In in vivo study, oral administration (100 mg/kg) of 3b significantly attenuated PD-associated behavioral deficits in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD and protected tyrosine hydroxylase-immunopositive dopaminergic neurons. Our results provided evidence that 3b might be a promising candidate for Parkinson's disease treatment.

RhIII-catalyzed oxidative olefination of vinylic C-H bonds: Efficient and selective access to Di-unsaturated α-amino acid derivatives and other linear 1,3-butadienes

Olefin(s) get-together! A RhIII-catalyzed oxidative cross-coupling of different olefins was developed, resulting in the formation of valuable linear butadiene products and especially di-unsaturated α-amino acid derivatives. 1,1-Di-, 1,2-di-, and 1,1,2-trisubstituted olefins could be coupled with styrenes and acrylates. In these reactions, remarkably high levels of chemo-, regio-, and stereoselectivity were obtained, rendering this a valuable synthetic tool. Copyright

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.