2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one

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Chemical Name:2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one
CAS No.:1610373-51-7
Molecular Formula:C₂₅H₂₄BrN₃O₆S
Molecular Weight:574.452
Hs Code.:

Synonyms:2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one

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Chemical Property of 2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one

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Technology Process of 2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one

There total 10 articles about 2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1610372-65-0
2-(5-(2-hydroxyethoxy)-6-(2-methyl-4-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one

: 1610373-51-7
2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one

Guidance literature:: With phosphorus tribromide; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

: 168015-04-1
2-bromo-6-(hydroxymethyl)pyridin-3-ol

: 1610373-51-7
2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 h / 60 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 22 h / 100 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 18 h / 120 °C

5.1: phosphorus tribromide / N,N-dimethyl-formamide / 2 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; phosphorus tribromide; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; In ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1610373-51-7
2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 60 °C / Inert atmosphere

3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 22 h / 100 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 18 h / 120 °C

6.1: phosphorus tribromide / N,N-dimethyl-formamide / 2 h / 60 °C

With ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; phosphorus tribromide; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; potassium hydroxide; In ethanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;