2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol

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Chemical Name:2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol
CAS No.:1416859-85-2
Molecular Formula:C₁₇H₁₂F₇N₅OS
Molecular Weight:467.37
Hs Code.:

Synonyms:2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol

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Chemical Property of 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol

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Technology Process of 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol

There total 5 articles about 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.94%

: 1544-53-2
2,2,2-trifluoroethanethiol

: 1416732-19-8,1443429-65-9
1-(5-bromopyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

: 1416859-85-2
2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol

Guidance literature:: 2,2,2-trifluoroethanethiol; With sodium; at 0 - 20 ℃; for 2h;

1-(5-bromopyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 16h;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1416859-85-2
2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -70 °C

2.2: 2 h / -70 - 20 °C

3.1: diethyl ether / 2 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 65 °C

5.1: sodium / 2 h / 0 - 20 °C

5.2: 16 h / 0 - 80 °C

With n-butyllithium; sodium; copper; potassium carbonate; In diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1416859-85-2
2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-((2,2,2-trifluoroethyl)thio)pyridin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: diethyl ether / 2 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 65 °C

4.1: sodium / 2 h / 0 - 20 °C

4.2: 16 h / 0 - 80 °C

With n-butyllithium; sodium; potassium carbonate; In diethyl ether; hexane; N,N-dimethyl-formamide;