Technology Process of 1L-1-azido-3,6-di-O-benzyl-1-deoxy-4,5-di-O-(p-methoxybenzyl)-scyllo-inositol
There total 13 articles about 1L-1-azido-3,6-di-O-benzyl-1-deoxy-4,5-di-O-(p-methoxybenzyl)-scyllo-inositol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
methanol;
at 20 ℃;
for 12h;
DOI:10.1021/jo010925c
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: NaH / dimethylformamide / 1.5 h / 0 - 20 °C
1.2: 84 percent / dimethylformamide / 3.5 h / 0 - 20 °C
2.1: 74 percent / p-TsOH*H2O; ethanol / 2 h / 45 °C
3.1: NaH / tetrahydrofuran / 1.5 h / 0 - 20 °C
3.2: nBu4NI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C
4.1: 13.2 g / AcOH; water / 1 h / 50 °C
5.1: 41 percent / 4-dimethylaminopyridine; 1,3-dicyclohexylcarbodiimide / CH2Cl2 / 3.5 h / -15 °C
6.1: 81 percent / NaOMe / methanol / 0.5 h / 20 °C
7.1: 84 percent / pyridine / 12 h / 20 °C
8.1: 97 percent / pyridine / 7 h / 20 °C
9.1: 89 percent / NaN3 / dimethylformamide / 11 h / 100 °C
10.1: 96 percent / NaOMe / methanol / 12 h / 20 °C
With
pyridine; dmap; sodium azide; ethanol; water; sodium methylate; sodium hydride; toluene-4-sulfonic acid; acetic acid; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo010925c
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 74 percent / p-TsOH*H2O; ethanol / 2 h / 45 °C
2.1: NaH / tetrahydrofuran / 1.5 h / 0 - 20 °C
2.2: nBu4NI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C
3.1: 13.2 g / AcOH; water / 1 h / 50 °C
4.1: 41 percent / 4-dimethylaminopyridine; 1,3-dicyclohexylcarbodiimide / CH2Cl2 / 3.5 h / -15 °C
5.1: 81 percent / NaOMe / methanol / 0.5 h / 20 °C
6.1: 84 percent / pyridine / 12 h / 20 °C
7.1: 97 percent / pyridine / 7 h / 20 °C
8.1: 89 percent / NaN3 / dimethylformamide / 11 h / 100 °C
9.1: 96 percent / NaOMe / methanol / 12 h / 20 °C
With
pyridine; dmap; sodium azide; ethanol; water; sodium methylate; sodium hydride; toluene-4-sulfonic acid; acetic acid; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo010925c
