(1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: (1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene
• CAS No.: 187993-43-7
• Molecular Formula: C₄₂H₄₁NO₃Si
• Molecular Weight: 635.878
• Mol file: 187993-43-7.mol

Synonyms:(1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Chemical Property of (1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

There total 1 articles about (1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(1R)-1-hydroxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene + (4,5-diphenyloxazol-2-yl)methyl bromide (81819-14-9) → (1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene (187993-43-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; -;

DOI:10.1016/j.bmcl.2005.04.042

Reference yield:

(1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene (187993-43-7) → (R)-5-(4,5-Diphenyl-oxazol-2-ylmethoxy)-5,6,7,8-tetrahydro-naphthalen-1-ol

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.04.042

Reference yield:

(1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene (187993-43-7) → (1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene (187991-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Bu₄NF / tetrahydrofuran

2: K₂CO₃ / dimethylformamide

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.04.042

upstream raw materials:

(4,5-diphenyloxazol-2-yl)methyl bromide

Downstream raw materials:

(1R)-1-(4,5-diphenyloxazol-2-yl)methyloxy-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene