(S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Base Information

Chemical Name:(S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate
CAS No.:1539320-74-5
Molecular Formula:C₂₉H₄₄N₄O₇
Molecular Weight:560.691
Hs Code.:

Synonyms:(S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

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Chemical Property of (S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

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Technology Process of (S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

There total 6 articles about (S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 22838-58-0
Boc-D-Val-OH

: 1539320-53-0
C₁₉H₂₇N₃O₄

: 1539320-74-5
(S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 12h;
DOI:10.1039/c3ob42016g

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1539320-74-5
(S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h

2: trifluoroacetic acid / dichloromethane / 2 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 2 h

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h

With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c3ob42016g

Reference yield:

: 2666-93-5
(S)-Leu-OMe

: 1539320-74-5
(S)-methyl 2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h

2: trifluoroacetic acid / dichloromethane / 2 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 2 h

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h

With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c3ob42016g