(4-(5-(aminomethyl)-2-fluorophenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone hydrochloride

Base Information

Chemical Name:(4-(5-(aminomethyl)-2-fluorophenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone hydrochloride
CAS No.:1411991-84-8
Molecular Formula:C₂₃H₂₃FN₂O₃*ClH
Molecular Weight:430.907
Hs Code.:

Synonyms:(4-(5-(aminomethyl)-2-fluorophenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone hydrochloride

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Chemical Property of (4-(5-(aminomethyl)-2-fluorophenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone hydrochloride

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Technology Process of (4-(5-(aminomethyl)-2-fluorophenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone hydrochloride

There total 2 articles about (4-(5-(aminomethyl)-2-fluorophenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1411992-75-0
C₃₀H₃₅FN₂O₅

: 1411991-84-8
(4-(5-(aminomethyl)-2-fluorophenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone hydrochloride

Guidance literature:: C₃₀H₃₅FN₂O₅; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 2h;

With trifluoroacetic acid;

With hydrogenchloride; In water;

Reference yield:

: 72337-68-9
6,7-dimethoxy-1-naphthalenecarboxylic acid

: 823195-19-3
tert-butyl 4-fluoro-3-(piperidin-4-yl)benzylcarbamate

: 1411991-84-8
(4-(5-(aminomethyl)-2-fluorophenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C

2: boron tribromide / dichloromethane / 2 h / 0 - 20 °C

With dmap; boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;