Benzenemethanesulfonamide, alpha,alpha-difluoro-4-methyl- (9CI)

Base Information

• Chemical Name: Benzenemethanesulfonamide, alpha,alpha-difluoro-4-methyl- (9CI)
• CAS No.: 803728-11-2
• Molecular Formula: C₈H₉F₂NO₂S
• Molecular Weight: 221.228
• Mol file: 803728-11-2.mol

Synonyms:Benzenemethanesulfonamide, alpha,alpha-difluoro-4-methyl- (9CI)

Chemical Property of Benzenemethanesulfonamide, alpha,alpha-difluoro-4-methyl- (9CI)

Chemical Property:

• PSA: 68.54000
• LogP: 3.11390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanesulfonamide, alpha,alpha-difluoro-4-methyl- (9CI)

There total 5 articles about Benzenemethanesulfonamide, alpha,alpha-difluoro-4-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N,N-bis(2,4-dimethoxybenzyl)-1,1-difluoro-1-(4-methylphenyl)methanesulfonamide (803728-01-0) → 1,1-difluoro-1-(4-methylphenyl)methanesulfonamide (803728-11-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 4.5h;

DOI:10.1021/ol048249z

Reference yield:

4-methylbenzylsulfonyl chloride (51419-59-1) → 1,1-difluoro-1-(4-methylphenyl)methanesulfonamide (803728-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / DMAP / tetrahydrofuran / 0 - 20 °C

2: 76 percent / N-fluorobenzenesulfonimide; NaHMDS / tetrahydrofuran / -78 - 20 °C

3: 56 percent / TFA / CH₂Cl₂ / 4.5 h / 0 °C

With dmap; sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol048249z

Reference yield:

4-Methylbenzyl bromide (104-81-4) → 1,1-difluoro-1-(4-methylphenyl)methanesulfonamide (803728-11-2)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium sulfite

2: 46 percent / DMAP / tetrahydrofuran / 0 - 20 °C

3: 76 percent / N-fluorobenzenesulfonimide; NaHMDS / tetrahydrofuran / -78 - 20 °C

4: 56 percent / TFA / CH₂Cl₂ / 4.5 h / 0 °C

With dmap; sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; trifluoroacetic acid; sodium sulfite; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol048249z

upstream raw materials:

N,N-bis(2,4-dimethoxybenzyl)-1,1-difluoro-1-(4-methylphenyl)methanesulfonamide

4-methylbenzylsulfonyl chloride

4-Methylbenzyl bromide

N,N-bis(2,4-dimethoxybenzyl)-1-(4-methylphenyl)methanesulfonamide

Refernces