7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

Base Information

Chemical Name:7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine
CAS No.:1187336-53-3
Molecular Formula:C₂₇H₃₇N₃O₅
Molecular Weight:483.608
Hs Code.:

Synonyms:7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

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Chemical Property of 7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

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Technology Process of 7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

There total 1 articles about 7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1187336-52-2
4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)benzonitrile

: 6303-75-9
2-pentylpyrazine

: 1187336-53-3
7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: 2-pentylpyrazine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -40 ℃; for 0.5h; Inert atmosphere;

4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)benzonitrile; In tetrahydrofuran; hexane; at -40 - 20 ℃; for 18.5h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; hexane; water;
DOI:10.1016/j.bmc.2009.06.024

Reference yield: 83.0%

: 1187336-53-3
7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

: 1187336-64-6
C₂₂H₂₉N₃O₄

Guidance literature:: 7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine; With methanol; toluene-4-sulfonic acid; at 20 ℃; for 2h; Inert atmosphere;

With potassium carbonate; In methanol; water;
DOI:10.1016/j.bmc.2009.06.024

Reference yield: 67.0%

: 1187336-53-3
7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

: 74-88-4
methyl iodide

: 1187336-54-4
7-butyl-5-methyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: 7-butyl-6-[4-(2-{2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethoxy}ethoxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2009.06.024