Technology Process of benzyl (2R,3S)-3-hydroxy-2-[(2-methyl-1,3-dioxolan-2-yl)methyl]piperidine-1-carboxylate
There total 9 articles about benzyl (2R,3S)-3-hydroxy-2-[(2-methyl-1,3-dioxolan-2-yl)methyl]piperidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: C20H21F6N3O2 / toluene / 48 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C
3: Dess-Martin periodane / dichloromethane / 16 h / 20 °C
4: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 1 h / -78 °C
5: triethylamine / dichloromethane / 1 h / 0 °C
6: sodium azide / N,N-dimethyl acetamide / 96 h / 80 °C / Inert atmosphere
7: potassium carbonate; palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C
8: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / Reflux
9: triethylamine / dichloromethane / 16 h / 0 - 20 °C
With
lithium aluminium tetrahydride; sodium azide; C20H21F6N3O2; palladium 10% on activated carbon; hydrogen; potassium tri-sec-butyl-borohydride; potassium carbonate; Dess-Martin periodane; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; toluene;
DOI:10.1055/s-0033-1338706
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate; palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / Reflux
3: triethylamine / dichloromethane / 16 h / 0 - 20 °C
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-0033-1338706