18871-63-1Relevant articles and documents
Enantioselective Pictet–Spengler Condensation to Access the Total Synthesis of (+)-Tabertinggine
Long, Dan,Zhao, Gaoyuan,Liu, Zhiqiang,Chen, Peiqi,Ma, Shiqiang,Xie, Xingang,She, Xuegong
supporting information, (2022/04/03)
A chiral phosphoric acid (CPA)-catalyzed enantioselective Pictet–Spengler condensation/lactamization cascade reaction was established, which paved the way of the collective synthesis of iboga-type indole alkaloids. Herein, we presented the asymmetric total synthesis of iboga-type indole alkaloid (+)-tabertinggine.
COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS
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, (2018/04/20)
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.
A shimizu non-aldol approach to the formal total synthesis of palmerolide A
Pujari, Sandip A.,Gowrisankar, Parthasarathy,Kaliappan, Krishna P.
, p. 3137 - 3151 (2012/08/28)
A formal total synthesis of palmerolide A has been accomplished by assembling three fragments by means of successive Julia-Kocienski olefination, Yamaguchi esterification, and ring-closing metathesis (RCM). Our initial efforts to combine the first two fragments through a Julia-Kocienski reaction between a secondary sulfone and a ketone were not successful; nevertheless, it was feasible between a primary sulfone and aldehyde. Yamaguchi esterification with the third fragment then set the stage for a RCM reaction. Initial failure of the RCM with a PMB-ether adjacent to the olefins and the difficulty in cleaving the PMB-ether prompted us to change the choice of protecting groups, which then paved the way to the macrocyclic core of palmerolide A.
