(S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

Base Information

• Chemical Name: (S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
• CAS No.: 1215006-07-7
• Molecular Formula: C₁₇H₂₂FN₃O₃
• Molecular Weight: 335.378

Synonyms:(S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

Chemical Property of (S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of (S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

There total 2 articles about (S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-amino-2-propene (107-11-9,30551-89-4) + (R)-methyl methanesulfonate (174649-09-3,2180621-71-8) → (S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one (1215006-07-7)

Guidance literature:

In isopropyl alcohol; at 120 ℃; for 4h; Inert atmosphere;

Reference yield: 45.0%

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine (168828-90-8) → (S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one (1215006-07-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

DOI:10.1016/j.tetlet.2020.151847

Reference yield: 82.0%

(S)-5-((allylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one (1215006-07-7) + acetyl chloride (75-36-5) → N-allyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide (1215006-10-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4.5h; Inert atmosphere;

upstream raw materials:

1-amino-2-propene

(R)-methyl methanesulfonate

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

Downstream raw materials:

N-allyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

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