ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate
• CAS No.: 1443300-51-3
• Molecular Formula: C₃₉H₄₁N₂O₁₀P
• Molecular Weight: 728.736
• Mol file: 1443300-51-3.mol

Synonyms:ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

There total 12 articles about ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

ethyl 3-(benzyloxy)-5-(dimethylcarbamoyl)-4-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate (1443300-50-2) + dibenzyloxy-chloromethylphosphoric acid (258516-84-6) → ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate (1443300-51-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 45h;

Reference yield:

4-methoxy-aniline (104-94-9) → ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate (1443300-51-3)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium acetate; sodium iodide / water / 3 h / 90 °C

2: water; sodium hydroxide / tetrahydrofuran; ethanol / 3 h / 40 °C

3: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C

5: sodium ethanolate / ethanol / 1.5 h / 85 °C

6: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C

7: potassium carbonate / N,N-dimethyl-formamide / 45 h / 0 - 20 °C

With water; sodium ethanolate; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; sodium iodide; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate (98269-30-8) → ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate (1443300-51-3)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium ethanolate / ethanol / 1 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3: water; sodium hydroxide / tetrahydrofuran; ethanol / 16 h / 50 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C

6: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C

7: potassium carbonate / N,N-dimethyl-formamide / 45 h / 0 - 20 °C

With palladium 10% on activated carbon; water; hydrogen; sodium ethanolate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 3-(benzyloxy)-5-(dimethylcarbamoyl)-4-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

dibenzyloxy-chloromethylphosphoric acid

diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

diethyl 3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylate

Downstream raw materials:

ethyl 5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-4-((phosphonooxy)methoxy)-1H-pyrrole-2-carboxylate