1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester

Base Information

Chemical Name:1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester
CAS No.:744217-32-1
Molecular Formula:C₂₄H₂₈O₄Si
Molecular Weight:408.569
Hs Code.:

Synonyms:1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester

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Chemical Property of 1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester

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Technology Process of 1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester

There total 5 articles about 1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 744217-31-0
1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-cyclopentanecarboxylic acid methyl ester

: 744217-32-1
1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester

Guidance literature:: 1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-cyclopentanecarboxylic acid methyl ester; With trimethylsilyl trifluoromethanesulfonate; triethylamine; at 0 ℃; for 0.5h;

With oxygen; palladium diacetate; In dimethyl sulfoxide; for 36h;
DOI:10.1081/NCN-200051900

Reference yield:

: 744217-30-9
1-hydroxymethyl-2-oxocyclopentanecarboxylic acid methyl ester

: 744217-32-1
1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / imidazole / dimethylformamide / 16 h / 20 °C

2.1: Et₃N; Me₃SiOSO₂CF₃ / 0.5 h / 0 °C

2.2: 88 percent / O₂ / Pd(OAc)2 / dimethylsulfoxide / 36 h

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-200051900

Reference yield:

: 10472-24-9,265317-94-0
methyl 2-oxocyclopentane-1-carboxylate

: 744217-32-1
1-(tert-butyldiphenylsilyloxymethyl)-2-oxo-3-cyclopentenecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / AcOH / H₂O / 23 h / 20 °C

2.1: 77 percent / imidazole / dimethylformamide / 16 h / 20 °C

3.1: Et₃N; Me₃SiOSO₂CF₃ / 0.5 h / 0 °C

3.2: 88 percent / O₂ / Pd(OAc)2 / dimethylsulfoxide / 36 h

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; acetic acid; triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.1081/NCN-200051900