biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide

Base Information

• Chemical Name: biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide
• CAS No.: 251563-63-0
• Molecular Formula: C₂₉H₃₆N₄OS
• Molecular Weight: 488.697
• Mol file: 251563-63-0.mol

Synonyms:biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide

Chemical Property of biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide

There total 5 articles about biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide (251563-63-0)

Guidance literature:

Multi-step reaction with 5 steps

1: NaBH(OAc)3 / 1,2-dichloro-ethane

2: NaBH(OAc)3 / 1,2-dichloro-ethane

3: aq. HCl

4: toluene / Heating

5: NaOEt / ethanol

With hydrogenchloride; sodium ethanolate; sodium tris(acetoxy)borohydride; In ethanol; 1,2-dichloro-ethane; toluene; 1: reductive amination / 2: reductive amination / 3: Hydrolysis / 4: Condensation / 5: cyclocondensation;

DOI:10.1016/S0960-894X(99)00454-0

Reference yield:

4-propylaminocyclohexan-1-one ethylene acetal (676124-70-2) → biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide (251563-63-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH(OAc)3 / 1,2-dichloro-ethane

2: aq. HCl

3: toluene / Heating

4: NaOEt / ethanol

With hydrogenchloride; sodium ethanolate; sodium tris(acetoxy)borohydride; In ethanol; 1,2-dichloro-ethane; toluene; 1: reductive amination / 2: Hydrolysis / 3: Condensation / 4: cyclocondensation;

DOI:10.1016/S0960-894X(99)00454-0

Reference yield:

biphenyl-4-carboxylic acid {4-[(4-oxo-cyclohexyl)-propyl-amino]-butyl}-amide → biphenyl-4-carboxylic acid {4-[(2-methylsulfanyl-5,6,7,8-tetrahydro-quinazolin-6-yl)-propyl-amino]-butyl}-amide (251563-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: NaOEt / ethanol

With sodium ethanolate; In ethanol; toluene; 1: Condensation / 2: cyclocondensation;

DOI:10.1016/S0960-894X(99)00454-0

upstream raw materials:

carbamimidothioic acid methyl ester

cyclohexanedione monoethylene ketal

4-propylaminocyclohexan-1-one ethylene acetal