Technology Process of (Z)-2-(2-(3-(3-(methylsulfonyl)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole
There total 10 articles about (Z)-2-(2-(3-(3-(methylsulfonyl)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methanesulfonic acid;
at 80 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: water; acetone / 5 - 60 °C
2.1: Oxone / acetone / 12 h / 20 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / 12 h / 90 °C
4.1: sodium hydrogen sulfide; magnesium chloride / N,N-dimethyl-formamide / 20 °C
5.1: hydrazine hydrate / N,N-dimethyl-formamide / 3 h
5.2: 90 °C
6.1: triethylamine / dichloromethane / 0 °C
7.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
7.2: Acidic conditions
8.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
9.1: hydrazine hydrate / 1 h / 0 °C / Inert atmosphere
10.1: methanesulfonic acid / 1 h / 80 °C / Inert atmosphere
With
4-methyl-morpholine; sodium hydrogen sulfide; Oxone; thionyl chloride; water; hydrazine hydrate; triethylamine; magnesium chloride; lithium hydroxide;
methanesulfonic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 0 °C
2.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
2.2: Acidic conditions
3.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
4.1: hydrazine hydrate / 1 h / 0 °C / Inert atmosphere
5.1: methanesulfonic acid / 1 h / 80 °C / Inert atmosphere
With
4-methyl-morpholine; water; hydrazine hydrate; triethylamine; lithium hydroxide;
methanesulfonic acid;
In
tetrahydrofuran; dichloromethane;
