2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol

Base Information

Chemical Name:2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol
CAS No.:180071-76-5
Molecular Formula:C₂₈H₃₈O₂Si
Molecular Weight:434.694
Hs Code.:

Synonyms:2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol

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Technology Process of 2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol

There total 8 articles about 2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1027646-67-8
(E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

: 180071-76-5
2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 2h;
DOI:10.1080/00397919608005229

Reference yield:

: 591-20-8
3-Bromophenol

: 180071-76-5
2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol

Guidance literature:: Multi-step reaction with 5 steps

1: 24 percent / triethylamine, Pd(OAc)2, tris(o-tolyl)phosphine / 100 °C

2: 1.) K₂CO₃, 2.) KI / 1.) DMSO, 90 deg C, 30 min, 2.) DMSO, 90 deg C, 5 h

3: 90 percent / H₂ / Pd/C / methanol / 10 h / Ambient temperature

4: 1.) lithium diisopropylamide / 1.) THF, -70 deg C, 1 h, 2.) hexamethylphosphorotriamide, -70 deg C -> r.t.

5: 90 percent / LiAlH₄ / diethyl ether / 2 h

With palladium diacetate; lithium aluminium tetrahydride; hydrogen; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium iodide; lithium diisopropyl amide; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1080/00397919608005229

Reference yield:

: 95-46-5
2-methylphenyl bromide

: 180071-76-5
2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-butyllithium / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C -> r.t., 2 h

2: 1.) K₂CO₃, 2.) KI / 1.) DMSO, 90 deg C, 30 min, 2.) DMSO, 90 deg C, 5 h

3: 90 percent / H₂ / Pd/C / methanol / 10 h / Ambient temperature

4: 1.) lithium diisopropylamide / 1.) THF, -70 deg C, 1 h, 2.) hexamethylphosphorotriamide, -70 deg C -> r.t.

5: 90 percent / LiAlH₄ / diethyl ether / 2 h

With lithium aluminium tetrahydride; n-butyllithium; hydrogen; potassium carbonate; potassium iodide; lithium diisopropyl amide; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1080/00397919608005229