N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide

Base Information

Chemical Name:N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide
CAS No.:1308869-86-4
Molecular Formula:C₃₅H₄₀N₄O
Molecular Weight:532.729
Hs Code.:

Synonyms:N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide

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Chemical Property of N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide

Chemical Property:

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Technology Process of N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide

There total 6 articles about N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(3-(2-(6-cyclopentenylpyrimidin-4-yl)cyclopent-2-enyl)-6-o-tolylquinolin-2-yl)pivalamide

: 1308869-86-4
N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; for 2h;

Reference yield:

: 16419-60-6
2-Methylphenylboronic acid

: 1308869-86-4
N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / butan-1-ol / 55 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / hexane; diethyl ether / 3 h / -70 - 0 °C / Inert atmosphere

3.2: 1 h / -70 - -50 °C

4.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 1-methyl-pyrrolidin-2-one / 10 h / 120 °C / Sealed vial; Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 2 h

With n-butyllithium; hydrogen; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; hexane; dichloromethane; butan-1-ol;

Reference yield:

: 791626-58-9
2-amino-6-bromoquinoline

: 1308869-86-4
N-(3-(2-(6-cyclopentylpyrimidin-4-yl)cyclopentyl)-6-o-tolylquinolin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / butan-1-ol / 55 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / hexane; diethyl ether / 3 h / -70 - 0 °C / Inert atmosphere

3.2: 1 h / -70 - -50 °C

4.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 1-methyl-pyrrolidin-2-one / 10 h / 120 °C / Sealed vial; Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 2 h

With n-butyllithium; hydrogen; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; hexane; dichloromethane; butan-1-ol;