2-methoxy-5-methyl-3,4-dihydro-2H-pyran

Base Information

• Chemical Name: 2-methoxy-5-methyl-3,4-dihydro-2H-pyran
• CAS No.: 38328-65-3
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.171
• Mol file: 38328-65-3.mol

Synonyms:2-methoxy-5-methyl-3,4-dihydro-2H-pyran

Chemical Property of 2-methoxy-5-methyl-3,4-dihydro-2H-pyran

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-methoxy-5-methyl-3,4-dihydro-2H-pyran

There total 2 articles about 2-methoxy-5-methyl-3,4-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methoxyethene (107-25-5,9003-09-2) + 2-methylpropenal (78-85-3,25120-30-3) → 1,4-dimethyl-6,8-dioxa-bicyclo[3.2.1]octane (194023-10-4) + 2-methoxy-5-methyl-3,4-dihydro-2H-pyran (38328-65-3) + 2,5-dimethyl-3,4-dihydro-2H-pyran-2-methanol (54004-34-1)

Guidance literature:

With sodium tetrahydroborate; hydroquinone; Yield given. Multistep reaction. Yields of byproduct given; 1.) 195 deg C, 500 lbs, 17 h, 2.) MeOH, 0 deg C to room temp.;

DOI:10.1016/S0022-2860(97)00001-X

Reference yield:

methoxyethene (107-25-5,9003-09-2) + 2-methylpropenal (78-85-3,25120-30-3) → 2-methoxy-5-methyl-3,4-dihydro-2H-pyran (38328-65-3) + 2,5-dimethyl-3,4-dihydro-2H-pyran-2-carbaldehyde (1920-21-4)

Guidance literature:

With hydroquinone; at 195 ℃; for 17h; under 25857.4 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0022-2860(97)00001-X

Reference yield: 52.0%

2-methoxy-5-methyl-3,4-dihydro-2H-pyran (38328-65-3) + (4-methylphenoxy)sulfonyl isocyanate (14754-43-9) → (3S,6R)-3-Formyl-6-methoxy-3-methyl-2-oxo-piperidine-1-sulfonic acid p-tolyl ester + (3R,6R)-3-Formyl-6-methoxy-3-methyl-2-oxo-piperidine-1-sulfonic acid p-tolyl ester

Guidance literature:

In chloroform-d1; for 96h; Ambient temperature;

DOI:10.1021/jo951868o

upstream raw materials:

methoxyethene

2-methylpropenal

Downstream raw materials:

2-methylpentanedial