6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide

Base Information

Chemical Name:6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide
CAS No.:1402652-20-3
Molecular Formula:C₂₀H₂₁N₃O₂S
Molecular Weight:367.472
Hs Code.:

Synonyms:6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide

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Chemical Property of 6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide

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Technology Process of 6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide

There total 10 articles about 6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402652-55-4
6-(2,4-dimethylthiophen-3-yl)-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carbonitrile

: 1402652-20-3
6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide

Guidance literature:: With hydroxylamine; In methanol; water; at 120 ℃; for 0.5h; Inert atmosphere; Microwave;

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 1402652-20-3
6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / diethyl ether / 0.33 h / -78 °C

2.1: tetrahydrofuran / 3 h / -40 °C

3.1: silica gel / chloroform / 2 h / Reflux

4.1: N-Bromosuccinimide / dichloromethane / 0.67 h / Inert atmosphere

5.1: boron tribromide / dichloromethane / 16 h / 0 - 2 °C / Inert atmosphere

5.2: 0 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5.5 h / 70 °C / Inert atmosphere

7.1: hydroxylamine / water; methanol / 0.5 h / 120 °C / Inert atmosphere; Microwave

With N-Bromosuccinimide; n-butyllithium; hydroxylamine; boron tribromide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform; water;

Reference yield:

: 14774-77-7
p-methoxyphenyllithium

: 1402652-20-3
6-(2,4-dimethylthiophen-3-yl)-N'-hydroxy-5-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-7-carboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 3 h / -40 °C

2.1: silica gel / chloroform / 2 h / Reflux

3.1: N-Bromosuccinimide / dichloromethane / 0.67 h / Inert atmosphere

4.1: boron tribromide / dichloromethane / 16 h / 0 - 2 °C / Inert atmosphere

4.2: 0 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5.5 h / 70 °C / Inert atmosphere

6.1: hydroxylamine / water; methanol / 0.5 h / 120 °C / Inert atmosphere; Microwave

With N-Bromosuccinimide; hydroxylamine; boron tribromide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; water;