3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Name:3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:185963-34-2
Molecular Formula:C₂₃H₃₁N₃O₈
Molecular Weight:477.514
Hs Code.:

Synonyms:3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of 3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of 3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 7 articles about 3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 185963-33-1
3,5-bis(((tert-butoxycarbonyl)amino)methyl)benzoic acid

: 185963-34-2
3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With N,N-methanetetraylbis; In tetrahydrofuran; Ambient temperature;
DOI:10.1002/hlca.19960790719

Reference yield:

: 499-06-9
3,5-dimethylbenzoic acid

: 185963-34-2
3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / conc. H₂SO₄ / 48 h / Heating

2: 84 percent / NBS, AIBN / methyl formate / 20 h / Heating; Irradiation

3: 75 percent / acetonitrile / 4 h / Heating

4: 98 percent / conc. aq. HCl / dioxane / 2 h / Heating

5: 86 percent / 1 M aq. NaOH / CH₂Cl₂ / 120 h / Ambient temperature

6: 92 percent / N,N-methanetetraylbis / tetrahydrofuran / Ambient temperature

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N,N-methanetetraylbis; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; Methyl formate; acetonitrile;
DOI:10.1002/hlca.19960790719

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 185963-34-2
3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 1 M aq. NaOH / CH₂Cl₂ / 120 h / Ambient temperature

2: 92 percent / N,N-methanetetraylbis / tetrahydrofuran / Ambient temperature

With sodium hydroxide; N,N-methanetetraylbis; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.19960790719