(R)-benzyl 3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate

Base Information

• Chemical Name: (R)-benzyl 3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate
• CAS No.: 1173425-32-5
• Molecular Formula: C₂₁H₁₈O₃
• Molecular Weight: 318.372
• Mol file: 1173425-32-5.mol

Synonyms:(R)-benzyl 3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate

Chemical Property of (R)-benzyl 3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-benzyl 3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate

There total 2 articles about (R)-benzyl 3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

benzyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate (135924-81-1) + methyl vinyl ketone (78-94-4,25038-87-3) → (R)-benzyl 3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate (1173425-32-5)

Guidance literature:

benzyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate; methyl vinyl ketone; With (R)-3,3'-bis(2,4-bis(trifluoromethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl phosphate; In m-xylene; at 40 ℃; for 24h;

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; In toluene; for 48h; optical yield given as %ee; enantioselective reaction; Reflux;

DOI:10.1002/anie.200901127

Reference yield:

C21H20O4 → (R)-benzyl 3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate (1173425-32-5)

Guidance literature:

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; In toluene; for 48h; enantioselective reaction; Reflux;

DOI:10.1002/anie.200901127

upstream raw materials:

benzyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate

methyl vinyl ketone