O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin

Base Information

• Chemical Name: O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin
• CAS No.: 77176-06-8
• Molecular Formula: C₁₈H₁₆ClN₃O₂
• Molecular Weight: 341.797

Synonyms:O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin

Chemical Property of O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin

Chemical Property:

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SDS file from LookChem

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Technology Process of O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin

There total 2 articles about O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(7-Chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin (77175-99-6) + acetyl chloride (75-36-5) → O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin (77176-06-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; Ambient temperature;

DOI:10.1002/ardp.19803131106

Reference yield:

7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione (4547-02-8) → O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin (77176-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / methanol / 1.5 h / Heating

2: 78 percent / Et₃N / tetrahydrofuran / Ambient temperature

With triethylamine; In tetrahydrofuran; methanol;

DOI:10.1002/ardp.19803131106

Reference yield: 10.0%

O-Acetyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin (77176-06-8) → 3-Acetoxy-7-chlor-2-methylamino-5-phenyl-3H-1,4-benzodiazepin (5969-98-2)

Guidance literature:

With acetic acid; In N,N-dimethyl-formamide; at 110 ℃; for 0.5h;

DOI:10.1002/ardp.19803131106

upstream raw materials:

N-(7-Chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-N-methylhydroxylamin

acetyl chloride

7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

Downstream raw materials:

7-Chlor-2-methylamino-5-phenyl-3-propionyloxy-3H-1,4-benzodiazepin

3-Acetoxy-7-chlor-2-methylamino-5-phenyl-3H-1,4-benzodiazepin

3-Acetoxy-7-chlor-2-(N-methylformamido)-5-phenyl-3H-1,4-benzodiazepin

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