tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate

Base Information

Chemical Name:tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate
CAS No.:1311202-93-3
Molecular Formula:C₂₅H₂₇Cl₂N₃O₅
Molecular Weight:520.412
Hs Code.:

Synonyms:tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate

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Chemical Property of tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate

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Technology Process of tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate

There total 3 articles about tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (1R,3R)-tert-butyl 3-(3-chloro-4-((Z)-N'-(5-chloro-6-isopropoxynicotinoyloxy)carbamimidoyl)phenoxy)cyclobutanecarboxylate

: 1311202-93-3
tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 60 ℃; for 1h;

Reference yield: 92.0%

: 187401-45-2
5-chloro-6-isopropoxynicotinic acid

: 1311202-56-8,1312023-77-0
tert-butyl trans-3-[3-chloro-4-(N'-hydroxycarbamimidoyl)phenoxy]cyclobutanecarboxylate

: 1311202-93-3
tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate

Guidance literature:: 5-chloro-6-isopropoxynicotinic acid; With di(2H-imidazol-2-yl)methanone; In acetonitrile; for 0.5h;

tert-butyl trans-3-[3-chloro-4-(N'-hydroxycarbamimidoyl)phenoxy]cyclobutanecarboxylate; In acetonitrile; at 20 ℃; for 0.5h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 70 ℃; for 1h;
DOI:10.1021/op300345v

Reference yield:

: 939768-64-6
tert-butyl (1s,3s)-3-hydroxycyclobutane-1-carboxylate

: 1311202-93-3
tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene / 0 - 30 °C

2: hydroxylamine / water; dimethyl sulfoxide / 15 h / 50 °C

3: Carbonyldiimidazole / acetonitrile

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 60 °C

With Carbonyldiimidazole; hydroxylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; dimethyl sulfoxide; toluene; acetonitrile;