trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid

Base Information

Chemical Name:trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid
CAS No.:1311231-54-5
Molecular Formula:C₂₁H₁₉Cl₂N₃O₅
Molecular Weight:464.305
Hs Code.:

Synonyms:trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid

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Chemical Property of trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid

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Technology Process of trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid

There total 5 articles about trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1311202-93-3
tert butyl trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylate

: 1311231-54-5
trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; triethylamine; In ethyl acetate; at 70 ℃;

Reference yield:

: C₂₄H₂₇Cl₂N₃O₅Si

: 1311231-54-5
trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid

Guidance literature:: With water; In ethyl acetate; at 20 ℃;
DOI:10.1021/op300345v

Reference yield:

: 939768-64-6
tert-butyl (1s,3s)-3-hydroxycyclobutane-1-carboxylate

: 1311231-54-5
trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene / 0 - 30 °C

2: hydroxylamine / water; dimethyl sulfoxide / 15 h / 50 °C

3: Carbonyldiimidazole / acetonitrile

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 60 °C

5: triethylamine; trimethylsilyl trifluoromethanesulfonate / ethyl acetate / 70 °C

With Carbonyldiimidazole; trimethylsilyl trifluoromethanesulfonate; hydroxylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; dimethyl sulfoxide; ethyl acetate; toluene; acetonitrile;