2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride

Base Information

• Chemical Name: 2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride
• CAS No.: 108719-16-0
• Molecular Formula: C₁₅H₁₈N₂O₃*2ClH
• Molecular Weight: 347.241
• Mol file: 108719-16-0.mol

Synonyms:2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride

Chemical Property of 2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride

There total 2 articles about 2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,3-bis-(2-acetylamino-phenoxy)-propan-2-ol (36884-16-9) → 2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride (108719-16-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 1h;

Reference yield:

2-(acetylamino)phenol (614-80-2) → 2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride (108719-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃ / dimethylformamide / 2 h / Heating

2: 90 percent / comcd. HCl / ethanol / 1 h

With hydrogenchloride; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield: 90.0%

2-hydroxy-1,3-bis(2-aminophenoxy)propane hydrochloride (108719-16-0) + chloroacetyl chloride (79-04-9) → 2-chloroacetoxy-1,3-bis[(2-chloroacetamido)phenoxy]propane (681160-89-4)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1055/s-2004-815938

upstream raw materials:

1,3-bis-(2-acetylamino-phenoxy)-propan-2-ol

2-(acetylamino)phenol

Downstream raw materials:

2-hydroxy-1,3-bis[(2-chloroacetamido)phenoxy]propane

2-chloroacetoxy-1,3-bis[(2-chloroacetamido)phenoxy]propane

2-hydroxy-1,3-bis[2-(2-nitrophenoxy)acetamidophenoxy]propane

2-chloroacetoxy-1,3-bis[2-(2-nitrophenoxy)acetamidophenoxy]propane

Refernces