diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate

Base Information

• Chemical Name: diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate
• CAS No.: 417712-10-8
• Molecular Formula: C₂₁H₂₇O₄P
• Molecular Weight: 374.417
• Mol file: 417712-10-8.mol

Synonyms:diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate

Chemical Property of diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate

There total 3 articles about diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diisopropyl (E)-(2-phenylethenyl)phosphonate (78463-00-0) + benzaldehyde (100-52-7) → diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate (417712-10-8)

Guidance literature:

diisopropyl (E)-(2-phenylethenyl)phosphonate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

benzaldehyde; In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)01089-4

Reference yield:

Tetraisopropyl methylenediphosphonate (1660-95-3) → diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate (417712-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 85 percent / tetrahydrofuran / 0.5 h / 0 °C

2.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

2.2: 97 percent / tetrahydrofuran / 0.25 h / -78 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; 1.2: Horner-Wadsworth-Emmons olefination;

DOI:10.1016/S0040-4020(01)01089-4

Reference yield:

benzaldehyde (100-52-7) → diisopropyl (E)-1-[hydroxy(phenyl)methyl]-2-phenylethenylphosphonate (417712-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 85 percent / tetrahydrofuran / 0.5 h / 0 °C

2.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

2.2: 97 percent / tetrahydrofuran / 0.25 h / -78 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; 1.2: Horner-Wadsworth-Emmons olefination;

DOI:10.1016/S0040-4020(01)01089-4

upstream raw materials:

diisopropyl (E)-(2-phenylethenyl)phosphonate

benzaldehyde

Tetraisopropyl methylenediphosphonate

Downstream raw materials:

1,3-diphenyl-1-propyne

1-(3-phenyl-1,2-propadienyl)benzene