β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid

Base Information

Chemical Name:β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid
CAS No.:61655-25-2
Molecular Formula:C₂₀H₂₂ClNO₄
Molecular Weight:375.852
Hs Code.:

Synonyms:β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid

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Chemical Property of β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid

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Technology Process of β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid

There total 10 articles about β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: C₂₁H₂₄ClNO₄

: 61655-25-2
β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1039/c3md00214d

Reference yield:

: ethyl β-{4-[2-(N-methylamino)-ethyl]-phenyl}-propionate hydrochloride

: 61655-25-2
β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid

Guidance literature:

Reference yield:

: C₁₇H₂₃NO₄

: 61655-25-2
β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: lithium hydroxide; water / tetrahydrofuran / 0 - 20 °C

With palladium 10% on activated carbon; water; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3md00214d