5-Chloro-2-methoxybenzoyl chloride

Base Information

• Chemical Name: 5-Chloro-2-methoxybenzoyl chloride
• CAS No.: 29568-33-0
• Molecular Formula: C8H6Cl2O2
• Molecular Weight: 205.04
• Hs Code.: 2918990090
• European Community (EC) Number: 822-266-4
• DSSTox Substance ID: DTXSID60495650
• Nikkaji Number: J2.258.225I
• Wikidata: Q82343893
• Mol file: 29568-33-0.mol

Synonyms:5-Chloro-2-methoxybenzoyl chloride;29568-33-0;5-Chloro-2-methoxybenzoylchloride;Benzoyl chloride, 5-chloro-2-methoxy-;5-Chloro-2-methoxy-benzoyl chloride;MFCD03208980;2-methoxy-5-chlorobenzoyl chloride;3-Chloro-6-methoxybenzoyl chloride;SCHEMBL257135;2-methoxy-5-chlorobenzoylchloride;DTXSID60495650;JVLUMHRASWENRU-UHFFFAOYSA-N;2-methoxy-5-chloro-benzoyl chloride;AKOS000114271;5-chloro-2-methoxybenzoic acid chloride;SY205382;BB 0244073;FT-0602559;EN300-239813;A819964;F2190-0073

Chemical Property of 5-Chloro-2-methoxybenzoyl chloride

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.546
• Boiling Point: 284.169°C at 760 mmHg
• Flash Point: 124.353°C
• PSA: 26.30000
• Density: 1.351g/cm³
• LogP: 2.72760
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 203.9744848
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

5-CHLORO-2-METHOXYBENZOYLCHLORIDE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Cl)C(=O)Cl

Technology Process of 5-Chloro-2-methoxybenzoyl chloride

There total 6 articles about 5-Chloro-2-methoxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-chloro-2-methoxybenzoic acid (3438-16-2) → 2-methoxy-5-chlorobenzoyl chloride (29568-33-0)

Guidance literature:

With thionyl chloride; for 4h; Reflux;

DOI:10.1002/chem.201900743

Reference yield: 60.0%

→ 2-methoxy-5-chlorobenzoyl chloride (29568-33-0)

Guidance literature:

Reference yield:

oxalyl dichloride (79-37-8) + 5-chloro-2-methoxybenzoic acid (3438-16-2) → 2-methoxy-5-chlorobenzoyl chloride (29568-33-0)

Guidance literature:

N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

5-chloro-2-methoxybenzoic acid

methyl 5-chloro-2-methoxybenzoate

oxalyl dichloride

2-methoxy-5-chlorobenzonitrile

Downstream raw materials:

4-(5-Chloro-2-methoxy-benzoylamino)-benzoic acid

4-[2-(2-methoxy-5-chloro-benzamido)-ethyl]-4'-hydroxy-biphenyl

(Z)-3-[4-(5-Chloro-2-methoxy-benzoylamino)-phenyl]-acrylic acid

4-[2-Methoxy-5-chloro-benzamido-methyl]-4'-hydroxy-biphenyl