Technology Process of (2R,3S)-2-benzyloxy-3-hydroxybutyrolactone
There total 5 articles about (2R,3S)-2-benzyloxy-3-hydroxybutyrolactone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / cyclohexane / 12 h / Dean-Stark; Heating
2.1: dichloromethane; lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 3 h / -30 °C / Reflux
2.2: -20 °C
3.1: toluene-4-sulfonic acid / 12 h / 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.75 h / -60 °C / Inert atmosphere
4.2: -20 °C / Inert atmosphere
5.1: bromine; sodium hydrogencarbonate / water / 2 h / 20 °C
6.1: hydrogenchloride / tetrahydrofuran / 12 h / 0 °C
With
hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; oxalyl dichloride; dichloromethane; bromine; sodium hydrogencarbonate; toluene-4-sulfonic acid; dimethyl sulfoxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; water;
DOI:10.1080/00397911.2012.714041
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / 12 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.75 h / -60 °C / Inert atmosphere
2.2: -20 °C / Inert atmosphere
3.1: bromine; sodium hydrogencarbonate / water / 2 h / 20 °C
4.1: hydrogenchloride / tetrahydrofuran / 12 h / 0 °C
With
hydrogenchloride; oxalyl dichloride; bromine; sodium hydrogencarbonate; toluene-4-sulfonic acid; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1080/00397911.2012.714041
